We talk about the signs of aging all the time, and for good reason. This is what we're talking about...
Our genetics dictate the markers of aging, but environmental factors can also induce or exacerbate them. Each hallmark contributes to the harm that happens and accumulates as people age, eventually leading to age-related diseases. The differences between chronological age (how many years since your birth) and biological age (how the aging process has damaged your body's physical and mental functions and appearance, in short, a time-dependent decline) are determined by the hallmarks of aging.
A growing body of evidence suggests the existence of a "metabolic clock" that regulates aging. The accumulation of metabolic changes, as well as a loss in metabolic balance and biological fitness, are all part of this clock. Targeting the fundamental age mechanisms is the key to combating aging and increasing Longevity.
Telomere attrition, genomic instability, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, loss of cellular homeostasis, deregulated nutrient sensing, epigenetic alterations, and altered intercellular communication are the nine cellular hallmarks of aging that have been identified so far . Each of these processes has been linked to metabolic changes.
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